CALL FOR PAPERS Endocrine and Metabolic Dysfunction during Aging and Senescence Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion
نویسندگان
چکیده
Benjamin T. Wall,* Marlou L. Dirks,* Tim Snijders, Jan-Willem van Dijk, Mario Fritsch, Lex B. Verdijk, and Luc J. C. van Loon Top Institute Food and Nutrition, Wageningen, The Netherlands; NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands; and Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
منابع مشابه
Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review
The ever increasing burden of an aging population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle atrophy (sometimes referred to as "simple" atrophy) and insulin resistance are "non-pathological" events resulting from sedentary behavior and peri...
متن کاملDifferences in postprandial protein handling after beef compared with milk ingestion during postexercise recovery: a randomized controlled trial.
BACKGROUND Protein consumed after resistance exercise increases postexercise muscle protein synthesis rates. To date, dairy protein has been studied extensively, with little known about the capacity of other protein-dense foods to augment postexercise muscle protein synthesis rates. OBJECTIVE We aimed to compare protein digestion and absorption kinetics, postprandial amino acid availability, ...
متن کاملCALL FOR PAPERS Endocrine and Metabolic Dysfunction during Aging and Senescence Hypoenergetic diet-induced reductions in myofibrillar protein synthesis are restored with resistance training and balanced daily protein ingestion in older men
Caoileann H. Murphy, Tyler A. Churchward-Venne, Cameron J. Mitchell, Nathan M. Kolar, Amira Kassis, Leonidas G. Karagounis, Louise M. Burke, John A. Hawley, and Stuart M. Phillips Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada; Department of Sports Nutrition, Australian Institute of Sport, Canberra, Australia; Exercise and Nutrition Research Group, School of Exercise ...
متن کاملCALL FOR PAPERS Endocrine and Metabolic Dysfunction during Aging and Senescence The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply
Mitchell WK, Phillips BE, Williams JP, Rankin D, Lund JN, Wilkinson DJ, Smith K, Atherton PJ. The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. Am J Physiol Endocrinol Metab 309: E450–E457, 2015. First published July 7, 2015; doi:10.1152/ajpendo.00112.2015.—Essential amino acids (EAA) are res...
متن کاملDose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men.
Aging impairs the sensitivity of skeletal muscle to anabolic stimuli, such as amino acids and resistance exercise. Beef is a nutrient-rich source of dietary protein capable of stimulating muscle protein synthesis (MPS) rates in older men at rest. To date, the dose-response of myofibrillar protein synthesis to graded ingestion of protein-rich foods, such as beef, has not been determined. We aime...
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